| ■ Early Tamiflu Might Benefit Transplant Patients With H1N1 Flu | 2010.07.09 |
| THURSDAY, July 8 (HealthDay News) -- Early treatment with antiviral drugs appears to help prevent serious illness and death in organ transplant patients with H1N1 swine flu, researchers say. Because they take immune system-suppressing drugs in order to prevent rejection of their new organs, transplant recipients may be at increased risk for flu virus infection and related complications, the authors of the new study explained in a news release about the study, which was published online July 8 in The Lancet Infectious Diseases. The study included 237 transplant recipients (154 adults, 83 children) in Canada, Europe and the United States who were infected with the pandemic H1N1 influenza strain A between April and December 2009. The patients had received their transplants a median of 3.6 years before being infected with H1N1 swine flu. The researchers said that 167 patients (71 percent) were admitted to the hospital. Of these, 37 (16 percent) were sent to the intensive care unit (ICU). Among ICU patients, 21 required mechanical ventilation. Ten of the patients (4 percent) died. Early treatment with antiviral drugs -- primarily Tamiflu (oseltamivir) -- was associated with reduced rates of ICU admission (8 percent of those treated within 48 hours versus 22 percent treated after 48 hours), hospital admission, need for mechanical ventilation and death. |